3-HO-PCE

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3-HO-PCE (3-Hydroxyeticyclidine) is a dissociative anesthetic compound belonging to the arylcyclohexylamine class, structurally and pharmacologically relate to substances like ketamine and phencyclidine (PCP). As a lesser-known research chemical, it has gain some attention in niche psychoactive communities for its potent dissociative and hallucinogenic effects.

Chemically, 3-HO-PCE is a hydroxylate analog of eticyclidine (PCE), featuring a hydroxy group in the third position of the phenyl ring. This modification is believe to influence its receptor binding profile and subjective effects. Like other dissociatives in its class, 3-HO-PCE primarily acts as an NMDA receptor antagonist, which leads to the classic dissociative effects such as anesthesia, detachment from reality, alter perception of time and space, and reduce bodily awareness. Anecdotal reports also suggest it may interact with opioid receptors, which could contribute to its unique psychoactive profile.

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The onset, duration, and intensity of 3-HO-PCE effects can vary depending on the dosage and route of administration. Typically, effects begin within 15–45 minutes when taken orally or intranasally, with the experience lasting 4–8 hours. Users often describe a deeply immersive state characterize by dissociation, internal introspection, euphoria, or sedation, although negative effects such as confusion, nausea, and motor impairment are also report.

As with many novel psychoactive substances, the safety profile of 3-HO-PCE is not well understood. There is limit research on its long-term effects, potential for neurotoxicity, or interaction with other substances. Overuse or high doses may increase the risk of psychosis, accidents, or lasting cognitive issues.

Due to its potency and relatively obscure status, 3-Hydroxyeticyclidine is generally use only by experience individuals within the research chemical or psychonaut community. Its legal status varies by country, often falling under analogue or blanket bans. Caution is strongly advise when handling or experimenting with this substance, and it should only be use in a harm-reduction context for scientific or educational purposes.